The pyruvate transporter hermes regulates autophagy and health by modulating ROS production - PubMed
5 hours ago
- #reactive oxygen species
- #pyruvate metabolism
- #autophagy
- The pyruvate transporter hermes (hrm) regulates autophagy and mTOR signaling by controlling pyruvate transport into mitochondria and the Krebs cycle.
- Loss of hrm increases reactive oxygen species (ROS) levels, and reducing ROS suppresses the autophagy and mTOR defects caused by hrm loss.
- In adult animals, hrm loss decreases lifespan and impairs autophagy in intestine tissues, linking pyruvate transport to organismal health.