Psoriasis: microbiome dysbiosis and pathogenic mechanisms - PubMed
5 hours ago
- #immune-response
- #microbiome-dysbiosis
- #psoriasis
- Psoriasis is a chronic immune-mediated inflammatory disease influenced by genetic predisposition, immune dysregulation, and environmental triggers.
- Microbial dysbiosis is a central regulatory node in psoriasis, affecting immune responses and clinical phenotypes.
- Gut dysbiosis reduces diversity, lowers Bacteroidetes/Firmicutes ratio, and depletes SCFA producers, compromising intestinal barrier integrity and promoting Th17 polarization.
- Cutaneous dysbiosis features Staphylococcus aureus dominance and fungal alterations, disrupting the skin barrier and amplifying IL-17-driven inflammation.
- Specific infections (HCV, H. pylori, Streptococcus) act as environmental triggers by activating these pathways.
- Biologics induce drug-specific microbiome shifts but carry infection risks that need management.
- Emerging microbiome-targeted interventions like probiotics show promise but face methodological inconsistencies.
- Future breakthroughs require a shift from correlation to mechanism, integrating standardized multi-omics approaches and personalized medicine strategies.