Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway - PubMed
4 hours ago
- #Asthma
- #Tim-3
- #ILC2
- Tim-3 agonists inhibit ILC2 activation, proliferation, and type 2 cytokine production via the NLK pathway.
- In vivo, Tim-3 agonists alleviate airway hyperreactivity and inflammation in asthma models.
- ILC2-specific Tim-3 deletion exacerbates airway hyperreactivity, confirming its role as an inhibitory checkpoint.