Single-Cell Studies Advance Understanding of the Genetic and Molecular Basis of Atherosclerosis - PubMed
3 hours ago
- #atherosclerosis research
- #vascular biology
- #single-cell genomics
- Single-cell and spatial genomics technologies are transforming the understanding of atherosclerosis by revealing cellular heterogeneity and dynamic changes in vascular smooth muscle and endothelial cells.
- These methods, including single-cell RNA-seq and single-cell ATAC-seq, help link genetic risk factors to specific cellular phenotypes and gene-regulatory networks in the disease.
- Spatial transcriptomics provides context by mapping molecular profiles within the plaque microenvironment, uncovering cell-cell signaling pathways.
- Emerging CRISPR-based single-cell methods are expected to bridge causal genetics and functional biology in atherosclerosis research.