Visceral adiposity, metabolic health and aging - PubMed
2 days ago
- #visceral adiposity
- #aging
- #metabolic health
- Visceral adipose tissue (VAT) is a metabolically active organ linked to metabolic dysfunction and aging.
- VAT accumulation is both a biomarker and a causal contributor to impaired metabolic health and reduced lifespan.
- The pathogenicity of VAT is context-dependent, influenced by factors like lipid spillover, chronic inflammation, genetic susceptibility, hormonal changes, and aging.
- VAT-derived substances (cytokines, exosomes, adipokines, lipotoxic metabolites) mediate harmful effects on metabolic health.
- Strategies to reduce VAT burden or neutralize its pathological impact are emerging as promising approaches for promoting metabolic health and longevity.