Lactate-driven IL8+ Tumor-Associated Macrophages Mediate Immunosuppression and Resistance to Immunotherapy in Clear Cell Renal Cell Carcinoma - PubMed
2 months ago
- #Tumor-Associated Macrophages
- #Immunotherapy
- #ccRCC
- IL8+ Tumor-Associated Macrophages (TAMs) are linked to immunosuppression and resistance to immunotherapy in clear cell renal cell carcinoma (ccRCC).
- High infiltration of IL8+ TAMs correlates with resistance to immune checkpoint blockade (ICB) in ccRCC.
- IL8+ TAMs exhibit a glycolysis-associated metabolic program and are responsive to lactate, which promotes IL8 expression.
- These TAMs display an immunosuppressive profile, leading to CD8+ T-cell dysfunction and regulatory T-cell accumulation.
- Blocking IL8 ex vivo alleviates CD8+ T-cell exhaustion and enhances anti-PD-1 therapy efficacy.
- Targeting IL8 may help overcome ICB resistance and improve immunotherapy outcomes in ccRCC.