Brain tumor susceptibility: from genetic predisposition syndromes to extended characterization of genomic determinants - PubMed
5 hours ago
- #brain tumors
- #precision therapy
- #genomics
- Central nervous system (CNS) tumor etiology and risk factors are poorly understood.
- Recent CNS tumor classifications link 19 genetic syndromes to brain neoplasms.
- Genetic predisposition may exist beyond hereditary syndromes, often studied via genome-wide association studies.
- Identifying genetic variants like SNPs that increase brain cancer risk is a current research focus.
- The review summarizes genomic risk factors, including tumor syndromes and alterations, for brain tumor formation.
- Understanding these factors could improve screening, prevention, and targeted precision therapies.