Hypusination of the translation factor eIF5A regulates mitochondrial tRNA processing to promote prostate cancer aggressiveness - PubMed
4 hours ago
- #hypusination
- #mitochondrial tRNA
- #prostate cancer
- Hypusination of eIF5A promotes prostate cancer aggressiveness by regulating mitochondrial tRNA processing.
- eIF5Ahyp supports mitochondrial metabolism and translation, enhancing tumor growth and metastasis.
- eIF5Ahyp controls the nuclear export and expression of MRPP3 mRNA, essential for mt-tRNA maturation.
- MRPP3 enhances mitochondrial metabolism and supports prostate cancer metastasis.
- Downregulation of eIF5Ahyp inhibits mitochondrial translation and tumor growth, which can be restored by MRPP3 expression.
- The study links hypusination to cancer progression by coordinating nuclear and mitochondrial genome expression.