Ceramide disrupts TM9SF2-PGK1 axis to redirect PD-L1 trafficking and enhance antitumor immunity - PubMed
6 hours ago
- #ceramide
- #antitumor immunity
- #PD-L1 trafficking
- Ceramide disrupts the TM9SF2-PGK1 axis to redirect PD-L1 trafficking, enhancing antitumor immunity.
- TM9SF2 regulates PD-L1 levels by promoting recycling via PGK1 and inhibiting degradation via HIP1R.
- Disruption of the TM9SF2-PGK1 complex reduces PD-L1 and boosts antitumor immune responses.
- Endogenous ceramide Cer(d18:1/26:0) destabilizes the complex, leading to PD-L1 lysosomal destruction.
- This reveals a druggable metabolic switch to improve cancer immunotherapy efficacy.