BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes - PubMed
5 hours ago
- #B lymphocytes
- #type 1 diabetes
- #BCL6
- BCL6 in T cells is crucial for promoting type 1 diabetes (T1D) by influencing the behavior of insulin-autoreactive B lymphocytes.
- Loss of BCL6 in T cells prevents diabetes even when anti-insulin B cells are present, reducing their activation and proliferation.
- T cells lacking BCL6 show decreased activation, and this deficiency redirects anti-insulin B cells away from extrafollicular niches, reducing atypical memory subsets in pancreas and lymph nodes.
- CD4+ T cells help license extrafollicular insulin-binding B cells, a process inhibited by BCL6 deficiency, supporting BCL6 inhibition as a potential immunotherapy for T1D.