Diminished transcriptional activity and splicing changes drive gene length-biased rewiring in the aging transcriptome - PubMed
5 hours ago
- #aging
- #transcription
- #RNA splicing
- Global reduction in transcriptional activity and frequency occurs with aging in mouse and human tissues.
- Aged tissues show preferential expression of short genes, including upregulation of short stress-response genes and downregulation of long neurodevelopmental genes.
- Increased aberrant splicing isoforms, such as mono-exonic and intron-retention types, are found in the aged brain.
- Interactions between RNA polymerase II and the Mediator complex decrease in chromatin of aged tissues, indicating dysregulation.
- Findings offer insights for aging research and potential targets for anti-aging therapies.