Immune escape mechanisms and therapeutic advances in virus-associated hematological malignancies - PubMed
5 hours ago
- #viral oncology
- #immune escape
- #hematological malignancies
- Virus-associated hematological malignancies are a key focus in oncology research due to their complex immune escape mechanisms.
- Viruses like EBV, HIV, HTLV-1, KSHV, HBV, and HCV play significant roles in the pathogenesis of hematological malignancies.
- Tumor cells evade host immune surveillance through multiple immune escape mechanisms.
- Cutting-edge therapeutic approaches include targeting viral proteins, immune checkpoint inhibitors, CAR-T therapy, oncolytic viruses, VST, and therapeutic vaccines.
- The review integrates molecular mechanisms with clinical applications to guide precision therapy in this field.