Single-Nucleus Transcriptomics Reveals Microglial State Transitions and Astrocytic Trajectory Divergence During Glial Remodeling Induced by Intracortical Electrode Implantation - PubMed
6 hours ago
- #bioinformatics
- #neuroscience
- #neuroinflammation
- Single-nucleus RNA sequencing (snRNA-seq) used to study the peri-implant microenvironment in rat motor cortex post-electrode implantation.
- Identified pathologic microglial subpopulation (marked by Gpnmb, SPP1, CD63) and scar-associated astrocytic subtype (characterized by Mctp1, Lrrc7).
- Neurons modulate microglial polarization and astrogliosis via CX3CL1-CX3CR1 signaling and PTN-ALK/Ptpprz1 interaction.
- Findings provide insights into improving the long-term biocompatibility of neural interfaces.