DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma - PubMed
2 days ago
- #ovarian cancer biomarkers
- #copy number variations
- #extracellular vesicles
- EV-DNA in ascites shows concordant copy number variations (CNVs) with tumor DNA in high-grade serous ovarian carcinoma.
- EV-DNA levels are higher in malignant ascites than benign cases, and can be elevated early in cancer development.
- CNV profiles from EV-DNA help predict response to PARP inhibitors, with a model using five genes showing high accuracy.