Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors - PubMed
4 hours ago
- #tumor microenvironment
- #spatial pharmacobiology
- #antibody delivery
- Introduces single-cell spatial pharmacobiology for mapping antibody delivery in tumors.
- Identifies stromal barriers like periostin-rich matrix and FAP+ fibroblasts hindering delivery.
- Applied to HNSCC and PDAC patients in clinical trials using panitumumab-IRDye800.
- Enables studies on drug resistance, dosing, and spatial biomarkers for precision oncology.