PDAP1 reprograms fatty acid metabolism and drives malignant transformation via HSPA8-Mediated ERK/MAPK activation in hepatocellular carcinoma - PubMed
6 hours ago
- #HCC
- #ERK/MAPK
- #fatty acid metabolism
- PDAP1 is overexpressed in hepatocellular carcinoma (HCC) and linked to poor survival outcomes.
- PDAP1 promotes HCC cell proliferation, migration, and invasion while inhibiting apoptosis.
- In vivo studies show PDAP1 enhances HCC growth and metastasis.
- PDAP1 stabilizes HSPA8 mRNA, activating the ERK/MAPK pathway.
- ERK/MAPK activation increases SREBP1-mediated fatty acid synthesis and reduces PPARα-driven fatty acid oxidation.
- Targeting PDAP1 could be a potential therapeutic strategy for HCC.