Unravelıng non-canonıcal Wnt sıgnalıng ın neural development and dısorders: a revıew of Wnt/PCP and Wnt/ca²⁺ pathways - PubMed
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- #Non-canonical Wnt signaling
- #Neural development
- #Neurological disorders
- Non-canonical Wnt signaling pathways, including Wnt/PCP and Wnt/Ca²⁺, are crucial for neural development and cellular homeostasis.
- These pathways regulate cytoskeletal dynamics, cellular polarity, calcium signaling, and processes like neural tube closure, neuronal migration, axon guidance, and synaptic plasticity.
- Dysregulation of non-canonical Wnt signaling contributes to neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder, spina bifida, Alzheimer's disease, and Parkinson's disease.
- Dishevelled (DVL) acts as a shared mediator across Wnt pathways, with downstream effectors including Rho GTPases, PKC, CaMKII, and NFAT.
- Emerging tools like CRISPR/Cas9 gene editing and human brain organoids help dissect pathway mechanisms and advance translational therapies.