Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling - PubMed
6 hours ago
- #MEK2-ERK2-SGK1
- #Paeoniflorin
- #Lung Injury
- Paeoniflorin (Pae) reduces hypobaric hypoxia-induced lung injury by targeting MEK2.
- Pae binds to specific MEK2 residues (K101, D156, S198) and enhances MEK2-ERK2 interaction.
- It alleviates oxidative stress, inflammation, mitochondrial dysfunction, and ferroptosis in lung injury.
- Pae's protective effects require MEK2 and depend on SGK1 upregulation via ERK2 activation.
- Findings suggest Pae as a potential therapy for hypoxia-related lung diseases.