Intestinal interleukin-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis during high-fat diet induced obesity in a study with male mice - PubMed
11 hours ago
- #GLP-1
- #metabolism
- #interleukin-22
- Intestinal IL-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis in high-fat diet-induced obesity in male mice.
- IL-22 deficiency reduces GLP-1 production and impairs glucose tolerance, while IL-22 administration restores GLP-1 levels and improves metabolic parameters.
- IL-22 activates STAT3 binding to the Gcg promoter, directly inducing GLP-1 production.
- Butyrate supplementation increases IL-22 levels and enhances GLP-1 production in an IL-22R-dependent manner, linking microbial metabolites to metabolic regulation.
- GLP-1 receptor antagonist exendin-9-39 abolishes the glucose-lowering effects of IL-22, confirming IL-22 acts primarily through GLP-1-dependent pathways.
- The study highlights IL-22-GLP-1 signaling as a potential therapeutic axis for metabolic disorders like obesity and diabetes.