Tumour Necrosis Factor-α Promotes Pyroptosis in Diabetic Liver Injury via the HMGB1/TLR4/MyD88/NF-κB Pathway - PubMed

4 hours ago

TNF-α plays a key role in promoting pyroptosis in diabetic liver injury.
Inhibition of TNF-α reduces hepatocyte pyroptosis and suppresses the HMGB1/TLR4/MyD88/NF-κB pathway.
In vivo studies show TNF-α inhibition improves liver function and histopathology without affecting blood glucose levels.
The study suggests targeting TNF-α as a potential therapeutic strategy for diabetic liver injury.

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