Causal association between glucagon-like peptide-1 receptor agonists and mental disorders: insight from genetic and real-world - PubMed
a day ago
- #genetic association
- #GLP-1 receptor agonists
- #mental disorders
- GLP-1 receptor agonists (GLP-1RAs) were studied for potential links to mental disorders using genetic and real-world evidence.
- Methods included Mendelian randomization, LDSC, Bayesian co-localization, and a meta-analysis of clinical studies.
- No genetic associations were found between GLP-1R and anxiety, bipolar affective disorders, chronic depression, depression, suicide, or schizophrenia.
- Eating disorders showed no genetic link in LDSC due to negative SNP-based heritability but had a significant difference in the meta-analysis (SMD = -0.71, PSMD = 0.006).
- Meta-analysis results showed no significant differences in suicidal ideation, anxiety, or depressive symptoms between GLP-1RA users and controls.
- The study concludes no genetic evidence supports a causal relationship between GLP-1RAs and the studied mental disorders.