Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle-mediated mRNA delivery in preclinical models - PubMed
14 hours ago
- #lipid nanoparticles
- #amino acid supplementation
- #mRNA delivery
- Amino acid supplementation (AAS) enhances lipid nanoparticle (LNP)-mediated mRNA delivery efficacy.
- AAS formulation (methionine, arginine, serine) improves LNP uptake and mRNA expression in epithelial cells in vitro.
- Coadministration of AAS with LNPs boosts mRNA expression 5- to 20-fold across cell types via clathrin-independent endocytosis.
- In vivo, AAS + LNPs enhance mRNA expression in preclinical models via multiple delivery routes.
- AAS + LNPs improve therapeutic outcomes in liver damage models and increase lung-targeted gene editing efficiency.