Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models - PubMed
5 hours ago
- #humanized antibodies
- #mouse models
- #SARS-CoV-2
- Study focuses on generating diverse antibody repertoires using a humanized mouse model with single VH1-2 and Vκ1-33 rearrangements.
- Immunization with SARS-CoV-2 D614G spike elicited antibodies neutralizing variants up to Omicron BA.2.754.
- A new mouse model with longer HC-CDR3s was developed, producing antibodies neutralizing Omicron subvariants.
- Four related humanized antibodies from the new model target a conserved hydrophobic patch in Omicron variants.
- Antibodies from both models showed similar potency and epitope recognition, reducing lung viral titers in BQ1.1 challenge.
- Findings validate the use of single human VH- and Vκ-rearranging mice for discovering neutralizing antibodies against emerging pathogens.