Postdiagnostic Anxiety and Depression Increase Rupture Risk and Mortality in Unruptured Intracranial Aneurysms - PubMed
11 hours ago
- #depression
- #anxiety
- #intracranial aneurysm
- Postdiagnostic anxiety and depression increase rupture risk and mortality in patients with unruptured intracranial aneurysms.
- A retrospective cohort study analyzed 127,361 adults with unruptured intracranial aneurysms using the TriNetX Global Collaborative Network.
- Patients with anxiety/depression had higher all-cause mortality (6.3% vs. 4.5%) and rupture rates (3.1% vs. 2.2%) compared to matched controls.
- Five-year survival was lower in the anxiety/depression cohort (93.7%) than in controls (95.5%).
- Preventive treatment showed a nonsignificant trend toward lower rates in the anxiety/depression group.
- Sensitivity analysis confirmed findings, with mortality and rupture risks remaining elevated in the anxiety/depression cohort.
- A dose-response pattern was observed for psychiatric medication adherence, with lower adherence linked to higher mortality risk.
- The study suggests integrated psychiatric assessment may be beneficial in managing unruptured intracranial aneurysms.