Realizing the potential of agonistic antibody immunotherapy - PubMed
2 hours ago
- #agonistic antibodies
- #immunotherapy
- #receptor signaling
- Agonistic antibodies mimic native ligands to initiate signaling in targeted receptors, with potential applications in autoimmune diseases and cancer immunotherapy.
- Despite preclinical promise, clinical benefits have been limited; recent progress in understanding mechanisms is key to engineering more effective antibodies.
- Focus includes TNFR superfamily proteins for cancer therapy, with insights into signaling by immune and cytokine receptors expanding treatment opportunities.
- The review summarizes advancements in antibody-initiated receptor signaling, clinical landscape, and strategies to improve safety and efficacy of agonistic antibody immunotherapy.