Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels - PubMed
3 hours ago
- #micrometastases
- #vascular permeability
- #nanoparticles
- Nanoparticles accumulate around avascular micrometastases due to enhanced permeability of nearby vessels.
- Micrometastases impose mechanical stress on adjacent vessels, activating β1 integrins and disrupting endothelial integrity.
- This vessel permeability mechanism facilitates nanoparticle enrichment and improves metastatic therapy outcomes.