Women with chronic pelvic pain can be stratified using multimodal assessment - PubMed
7 hours ago
- #Chronic Pelvic Pain
- #Multimodal Assessment
- #Stratification
- Chronic pelvic pain (CPP) is a common and burdensome symptom in women, often leaving many with persistent pain despite current clinical management.
- The TRiPP project aims to better phenotype CPP through multimodal assessment, integrating questionnaire, physiological, and biological data.
- The study included 108 women with CPP (including endometriosis-associated pain, bladder pain syndrome, and pelvic pain with no underlying pathology) and 50 pain-free controls.
- Compared to controls, CPP participants reported significantly higher levels of fatigue, poorer sleep, anxiety, depression, pain catastrophizing, and more childhood trauma.
- No significant differences were observed in physiological measures between CPP participants and controls.
- Latent profile analysis identified three distinct CPP subgroups, differentiated primarily by questionnaire data rather than physiological measures.
- Cluster 1 represents a group with higher-impact pain, potentially associated with nociplastic mechanisms.
- The findings support alternative approaches to stratifying CPP separate from standard diagnostic groupings.
- Questionnaire measures play a key role in stratification, facilitating translation to clinical settings.
- Further research is needed to determine if differing therapeutic approaches are appropriate for each identified cluster.