COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response - PubMed
6 days ago
- #immunotherapy
- #NSCLC
- #COPD
- COPD is a common comorbidity in NSCLC and is linked to better responses to anti-PD-1 therapy.
- COPD induces epithelial remodeling, leading to a distinct basal-like tumor cell population in NSCLC.
- These cells activate the CXCL14-CXCR4 signaling axis, recruiting macrophages that produce CXCL9.
- This creates a microenvironment that enhances cytotoxic T cell infiltration.
- The tumor-macrophage recruitment circuit is enriched in NSCLC patients with good responses to neoadjuvant anti-PD-1 therapy.
- The findings suggest a mechanistic link between COPD and improved PD-1 blockade efficacy.
- The tumor-macrophage axis could serve as a predictive biomarker and therapeutic target for immunotherapy.