The role of sex hormones in severe mental illness: A genetic exploration - PubMed
5 hours ago
- #genetics
- #hormones
- #mental-health
- Study explores genetic links between sex hormones and severe mental illnesses (SMI) like depressive disorder, bipolar disorder, and schizophrenia-spectrum disorder.
- Uses genetic correlation and Mendelian Randomization (MR) to examine bidirectional causal effects between sex hormone traits and SMI.
- Finds modest genetic correlations between estrogen/testosterone levels and depressive disorder/schizophrenia-spectrum disorder, varying by direction and sex.
- Limited causal effects found, except weak evidence for testosterone increasing schizophrenia-spectrum disorder risk in males, mediated by CRP.
- Suggests need for larger, more precise studies to understand hormonal impacts on SMI and identify vulnerable individuals.