Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors - PubMed
3 months ago
- #Alzheimer's disease
- #neuroinflammation
- #microglia
- INPP5D interacts with RIPK1 to suppress its kinase activation, impacting Alzheimer's disease risk.
- Microglial INPP5D deficiency promotes RIPK1-mediated induction of proinflammatory genes and mediators.
- RIPK1-regulated microglial signatures are found in Alzheimer's disease-related microglial subtypes.
- INPP5D deficiency leads to neuronal TDP-43 pathology, neuronal loss, and motor dysfunction.
- INPP5D acts as a regulator of RIPK1-mediated neuroinflammation in aging-related neurodegenerative diseases.