Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations - PubMed
5 hours ago
- #Signaling Pathways
- #Diabetic Kidney Disease
- #Traditional Chinese Medicine
- Diabetic kidney disease (DKD) is a major complication of diabetes, leading to end-stage renal disease and death.
- Current clinical drugs for DKD have limitations, including side effects and inability to halt disease progression.
- Traditional Chinese medicine (TCM) offers multi-target and multi-pathway interventions with low toxicity, making it suitable for chronic diseases like DKD.
- Key signaling pathways in TCM treatment of DKD include Nrf2, TGF-β/Smad, NF-κB/NLRP3, MAPK, and PI3K/AKT.
- Notable TCM agents for DKD include astragaloside IV, Huangkui capsule, Liuwei Dihuang pill, and baicalin.
- This review consolidates signaling pathways targeted by TCM in DKD, identifying potential therapeutic targets and drugs.