Identification of circulatory neuro-related proteins in Parkinson's disease: an integrated genetic-proteomic-clinical study - PubMed
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- #Parkinson's disease
- #Genetic-proteomic study
- #Neuro-related proteins
- Identified 59 neuro-related proteins associated with Parkinson's disease (PD), including 4 linked to risk, 7 to age at onset, and 58 to progression.
- Used Mendelian randomization and integrated genetic-proteomic-clinical data from large cohorts (33,647 PD patients and 449,056 controls).
- Found shared genetic variants for TDGF1, PVR, and IL5RA with disease progression.
- Evaluated 47 proteins as potential druggable targets for PD therapy.
- Pathway analysis highlighted cytokine-receptor interactions, neuroimmune modulation, and axon guidance.
- Differentially expressed proteins (BMP-4, DDR1, GDNF, LAT, MANF) correlated with PD symptom severity in a case-control study.
- Funded by multiple national and institutional grants, including the National Natural Science Foundation of China.