Glycan-Binding Proteins in Immunity - PubMed
5 hours ago
- #immune-regulation
- #immunology
- #glycobiology
- Glycan-binding proteins (GBPs) like Galectins, Siglecs, and C-type lectin receptors (CLRs) regulate immune cell functions.
- GBPs interpret glycan-encoded information to shape immune responses in T, B, and myeloid cells.
- Galectins function through extracellular and intracellular mechanisms by binding β-galactosides.
- Siglecs recognize sialoglycans and initiate immunoregulatory signaling on immune cells.
- CLRs detect glycans on pathogens and host cells, aiding immune sensing and modulation.
- GBPs integrate intrinsic immune programs with environmental and intracellular signals.
- Dysregulation of glycan-GBP interactions can lead to immune dysfunction and pathology.
- Targeting glycoimmune checkpoints may offer new immunotherapy approaches.