Bowel-Associated Dermatosis and Arthritis Syndrome (BADAS) - A Literature Review With Diagnostic and Therapeutic Implications and a Report of Two Cases of BADAS Associated With Inflammatory Bowel Dise
11 hours ago
- #Inflammatory Bowel Disease
- #Neutrophilic Dermatosis
- #BADAS
- BADAS is a rare neutrophilic dermatosis with symptoms like skin eruptions, joint inflammation, and systemic issues.
- Originally linked to intestinal bypass, BADAS is now increasingly associated with inflammatory bowel disease (IBD).
- A literature review identified 21 IBD-associated BADAS cases, with a female predominance (65%) and mean onset age of 36.7 years.
- Ulcerative colitis and Crohn's disease were the most common underlying conditions in BADAS cases.
- Diagnosis often coincides with IBD, suggesting skin and joint symptoms should prompt gastrointestinal evaluation.
- Common abnormalities include leukocytosis, anemia, and elevated inflammatory markers.
- Skin histopathology typically shows neutrophilic dermatosis, often with leukocytoclastic vasculitis.
- Two case studies highlight successful treatment approaches: one with antibiotics, corticosteroids, cyclosporine, and azathioprine; another with antibiotics and infliximab.
- A proposed management approach includes antibiotics, optimizing IBD therapy, and early use of biologics like anti-TNF for severe cases.