Hashimoto's Thyroiditis Beyond Thyroid Hormones: A Systematic Review of Autoimmunity, Inflammation, and Multidimensional Burden - PubMed
5 hours ago
- #autoimmunity
- #quality of life
- #Hashimoto's thyroiditis
- Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease.
- Persistent symptoms in HT patients suggest autoimmunity and inflammation affect quality of life (QoL) beyond thyroid hormone levels.
- HT patients, often euthyroid or on levothyroxine, report lower QoL, especially in cognitive, affective, and vitality domains.
- Elevated anti-thyroid antibodies (anti-TPO, anti-Tg) negatively correlate with QoL, unlike TSH and thyroid hormone levels.
- Interventions like total thyroidectomy or therapies reducing antibody levels show improvements in fatigue and QoL.
- Some studies found no direct link between antibody levels and symptom severity, indicating methodological variability.
- HT impacts QoL through chronic autoimmunity and low-grade inflammation, challenging a purely TSH-centric treatment model.
- A patient-centered approach integrating immunological, psychological, and subjective outcomes is recommended.
- More longitudinal and interventional trials are needed to establish causal pathways and personalize therapy.