Mucosal vaccination clears Clostridioides difficile colonization - PubMed
3 days ago
- #mucosal immunity
- #vaccination
- #Clostridioides difficile
- Mucosal vaccination effectively clears Clostridioides difficile (C. difficile) colonization.
- Previous parenteral vaccines failed to reduce pathogen burden, unlike mucosal vaccines.
- Mucosal immunization induces fecal IgG responses and a TH17-skewed immune response in the colon.
- This vaccination method protects against morbidity, mortality, and recurrence of infection.
- The study highlights the superiority of mucosal over parenteral vaccination routes for C. difficile.