All-in-one: a CGRP-encapsulated Rh-GelMA supramolecular dual-network hydrogel orchestrating immune-vascular coupling for diabetic wound healing - PubMed
2 days ago
- #Diabetic wound healing
- #Immune modulation
- #Hydrogel biomaterials
- The researchers developed a supramolecular double-network hydrogel called CGRP@Rh-GelMA, combining self-assembled rhein and UV-crosslinked GelMA for enhanced mechanical strength, adhesion, and dual-drug release.
- In vitro, the hydrogel demonstrated broad-spectrum antibacterial activity and ROS-scavenging, reduced NETosis markers (MPO and H3Cit), and promoted a shift toward M2-like macrophages.
- It also enhanced endothelial cell migration and vascular network formation, indicating pro-angiogenic effects.
- In diabetic rat models, CGRP@Rh-GelMA accelerated wound healing by improving immune microenvironment remodeling and neovascularization, leading to better tissue formation and collagen deposition.
- Proteomic analysis showed suppression of NF-κB signaling and NETosis, highlighting its dual role in coordinating immune and vascular repair for diabetic wound treatment.