Mitochondrial oxidative stress to PANoptosis: Current evidence and therapeutic implications for neurological diseases - PubMed
11 hours ago
- #Neurological diseases
- #Mitochondrial dysfunction
- #PANoptosis
- Mitochondrial oxidative stress is a key driver of neurological diseases like Alzheimer's, Parkinson's, and spinal cord injury.
- PANoptosis is a newly identified cell death pathway combining pyroptosis, apoptosis, and necroptosis, worsening neuroinflammation and neuron loss.
- Mitochondrial oxidative stress triggers PANoptosis via mechanisms like ROS overproduction, mitochondrial DNA damage, and impaired mitochondrial dynamics.
- The review explores the interplay between mitochondrial oxidative stress and PANoptosis in neurological diseases.
- Potential therapeutic strategies targeting these pathways show promise in reducing neuroinflammation and neuronal death.