Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk - PubMed
2 months ago
- #aging
- #dendritic cells
- #vaccine efficacy
- Aging impairs immune function and reduces vaccine efficacy.
- Dendritic cells (DCs) show migration defects in aged mice, contributing to diminished vaccine responses.
- Single-cell RNA sequencing reveals dysfunction-associated gene signatures in migratory DCs in aging.
- Oral yeast-derived nanoparticles boost CCR7 expression in gut DCs, improving their migration to lymph nodes.
- This strategy enhances vaccine-induced immunity in aged animals, offering a noninvasive method to improve vaccine efficacy.