cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma - PubMed
5 hours ago
- #cIAP1
- #tumor suppressor
- #Ewing sarcoma
- Ewing sarcoma (EwS) is a highly aggressive pediatric cancer driven by EWSR1::ETS fusion oncoproteins, primarily EWSR1::FLI1.
- cIAP1 (BIRC2), typically oncogenic in other cancers, is minimally expressed in EwS and acts as a tumor suppressor when re-expressed.
- Re-expression of cIAP1 in EwS cells suppresses proliferation, clonogenic growth, and 3D spheroid formation in vitro.
- Transcriptomic and proteomic analyses show that low cIAP1 enhances proliferation-related gene signatures, which are inhibited upon its re-expression.
- In vivo xenograft models demonstrate that cIAP1 re-expression reduces tumor growth, mitotic activity, and Ki-67 positivity while increasing necrosis and apoptosis.
- The study highlights cIAP1 as a prognostically relevant, EWSR1::FLI1-regulated hub, offering a potential therapeutic strategy for EwS.