Using Local sIgE Threshold to Refine the Diagnosis of Local Allergic Rhinitis - PubMed
5 hours ago
- #biomarker
- #allergic rhinitis
- #type 2 inflammation
- Local allergic rhinitis (LAR) is a chronic rhinitis phenotype with localized IgE production but no systemic atopy.
- Diagnosis of LAR traditionally relies on nasal allergen challenge (NAC), but its correlation with immunological endotype is unclear.
- This study evaluates a local specific immunoglobulin E (sIgE) threshold for diagnosing house dust mite (HDM)-sensitized LAR.
- The study involved 181 chronic rhinitis patients without systemic atopy and 146 healthy controls.
- A diagnostic threshold for local sIgE was established using the 95th percentile from the healthy cohort.
- Stratification using the local sIgE threshold (≥ 0.14 kUA/L) identified a group with elevated type 2 cytokines (IL-4, IL-5, CCL5, CCL11).
- Local sIgE levels positively correlated with type 2 cytokines in the sIgE-high group.
- The local sIgE threshold offers a biomarker-driven approach to refine LAR diagnosis and improve targeted therapy selection.