Structural insights into predicted protein-protein interactions and protein complexes in the human proteome - PubMed
5 hours ago
- #Human Interactome
- #Protein-Protein Interactions
- #Structural Modeling
- The study builds on previous large-scale computational predictions of human protein-protein interactions (PPIs) to provide near-atomic resolution insights into the human interactome.
- It presents additional examples of predicted PPIs relevant to DNA repair, mitochondrial function, and organelle biogenesis, offering mechanistic hypotheses for protein function and pathway crosstalk.
- Binary PPI predictions are assembled into models of higher-order multi-protein complexes, revealing new candidate subunits and organizational principles.
- Structural mapping of disease-associated mutations shows many mutations lie within predicted interaction interfaces, suggesting how genetic variation disrupts protein networks and contributes to pathology.
- The research demonstrates how computational predictions can generate detailed mechanistic insights, hypotheses for functional studies, and expand structural and functional annotation of the human interactome.