Predisposition to ALL and Solid Tumors Rather Than Bone Marrow Failure in FANCM-Associated Fanconi Anemia - PubMed
5 hours ago
- #Cancer Predisposition
- #Fanconi Anemia
- #FANCM Variants
- FANCM-associated Fanconi anemia patients do not develop bone marrow failure, unlike other FA genotypes.
- FANCM patients often present with malignancies first, including oral cancers and acute lymphoblastic leukemia (ALL).
- Diagnosis of FA in FANCM patients is delayed due to atypical presentation, leading to severe toxicity from cancer treatments.
- Recognition of this subtype is critical for early detection and tailored therapeutic approaches.