Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients - PubMed
21 hours ago
- #gut microbiota
- #NSCLC
- #prognostic nutritional index
- High prognostic nutritional index (PNI ≥46.2) predicts improved 5-year survival in postoperative NSCLC patients.
- High PNI associates with enrichment of SCFA-producing gut bacteria (e.g., Akkermansia, Eubacterium hallii) and higher butyrate/isovalerate levels.
- SCFA levels correlate with increased CD8+ T cell infiltration in tumors.
- Fecal microbiota transplantation from high-PNI patients reduces lung tumor growth in mice.
- Oral administration of A. muciniphila, E. hallii, or butyrate suppresses tumor growth and enhances CD8+ tumor-infiltrating lymphocytes.
- PNI and gut microbiota-SCFA axis are prognostic biomarkers and potential immunomodulatory targets for early-stage NSCLC.