Endometrial organoids to model benign disorders affecting the endometrium - PubMed
6 hours ago
- #disease modeling
- #endometrial organoids
- #benign disorders
- The endometrium is crucial for reproductive health, but current models for benign endometrial disorders are limited.
- Traditional animal models and 2D cell cultures fail to replicate human-specific features or maintain physiological complexity.
- Endometrial epithelial organoids (EEOs) are 3D structures that mimic glandular features, including polarity, hormone response, and patient-specific signatures.
- EEOs are used to model conditions like endometriosis, adenomyosis, uterine fibroids, implantation failure, aging, endometritis, and hypoplasia.
- While not fully replicative, EEOs bridge basic research and clinical understanding of endometrial disorders.