Discovery of a Selective DNMT1 Degrader with a Unique Molecular Glue Mechanism as a Potential Therapeutic Agent for Acute Myeloid Leukemia - PubMed
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- #acute myeloid leukemia
- #molecular glue mechanism
- #DNMT1 degrader
- Discovery of a selective DNMT1 degrader (6k) with a unique molecular glue mechanism.
- 6k promotes direct interaction between DNMT1 and UHRF1 proteins under cell-free conditions.
- Demonstrates potent inhibitory effects on acute myeloid leukemia (AML) cells in vitro and in vivo.
- Effectively suppresses proliferation of primary AML cells and extends survival in PDX models.
- Exhibits favorable bioavailability and safety, indicating potential for therapeutic development.