Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study - PubMed
3 days ago
- #MAFLD
- #Knee Osteoarthritis
- #Inflammation
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is linked to an 18% higher risk of knee osteoarthritis (KOA) based on a prospective cohort study.
- The study involved 303,604 participants from the UK Biobank without baseline osteoarthritis, followed for a median of 13.67 years.
- MAFLD was defined using the fatty liver index and metabolic criteria, with fibrosis severity assessed via the Fibrosis-4 score.
- Risk of KOA increased with the severity of fibrosis in MAFLD patients.
- Among MAFLD subtypes, only MAFLD-overweight/obesity showed a significant association with KOA.
- High-sensitivity C-reactive protein (hs-CRP) mediated 8.94% of the association between MAFLD and KOA, indicating a partial role of inflammation.
- The findings suggest MAFLD affects musculoskeletal health, advocating for integrated management strategies.