TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size - PubMed
5 hours ago
- #HIV reservoir
- #epigenetic control
- #TGF-β
- TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size.
- Epigenetic programming of myeloid and CD4+ T cells promotes decay of the HIV reservoir.
- Coordinate regulation of gene expression and chromatin accessibility associated with decay of viral DNA in treated SIV-infected macaques.
- TGF-β/SMAD signaling suppresses antiviral activity via histone deacetylases, reducing chromatin accessibility of IRFs and STATs.
- HDAC inhibitors restore antiviral response in the presence of TGF-β.
- IL-6 induction in low viral DNA macaques amplifies antiviral network through IRF9.
- Overlapping molecular cascade identified in HIV elite controllers maintaining small reservoirs without treatment.
- Insights provided for strategies in HIV cure interventions.