Effect of Medical Therapies for Endometriosis on Bone Health: A Systematic Review and Meta-analysis - PubMed
6 hours ago
- #endometriosis
- #hormonal therapy
- #bone health
- The systematic review evaluates the effect of hormonal therapies for endometriosis on bone mineral density (BMD).
- GnRH agonists with add-back therapy showed a decrease in BMD at 6 months (-0.89%) and 12 months (-1.50%).
- Subgroup analysis revealed leuprolide and goserelin with add-back therapy also decreased BMD at 6 months.
- Dienogest was associated with lower BMD at 6 months (-0.83%) and 12 months (-1.91%), but with high heterogeneity between studies.
- GnRH antagonists decreased BMD at 6 months (-2.17%), though most studies lacked add-back therapy.
- Data on depot medroxyprogesterone acetate (DMPA) could not be meta-analyzed due to insufficient studies.
- The clinical significance of BMD reduction remains uncertain, emphasizing the need for expert consensus on bone health management in long-term hormonal therapy.