A drug-microbiome-drug interaction impacts co-prescribed medications for Parkinson's disease - PubMed
6 hours ago
- #drug-drug interactions
- #Parkinson's disease
- #gut microbiome
- A drug-microbiome-drug interaction influences co-prescribed Parkinson's disease medications like COMT inhibitors and levodopa.
- COMT inhibitors exhibit antibiotic properties affecting the gut microbiome and altering levodopa metabolism in vitro and ex vivo.
- Iron availability modulates COMT inhibitor antibiotic activity, with extracellular iron reducing and intracellular iron protecting against effects.
- Co-administration of COMT inhibitors and levodopa leads to individual-specific changes in drug metabolism linked to microbiome composition.
- The study emphasizes the microbiome's role in drug-drug interactions and suggests microbial features for predicting individual drug responses.